منابع مشابه
Cordon-Bleu: A New Taste in Actin Nucleation
Polymerization of actin filaments powers many dynamic cellular events and is directed by a small group of actin nucleators. In this issue, Ahuja et al. (2007) identify and characterize a new actin nucleator called cordon-bleu (Cobl) that may drive morphogenesis of the central nervous system during development.
متن کاملCordon bleu promotes the assembly of brush border microvilli
Microvilli are actin-based protrusions found on the surface of diverse cell types, where they amplify membrane area and mediate interactions with the external environment. In the intestinal tract, these protrusions play central roles in nutrient absorption and host defense and are therefore essential for maintaining homeostasis. However, the mechanisms controlling microvillar assembly remain po...
متن کاملCordon-Bleu Is an Actin Nucleation Factor and Controls Neuronal Morphology
Despite the wealth of different actin structures formed, only two actin nucleation factors are well established in vertebrates: the Arp2/3 complex and formins. Here, we describe a further nucleator, cordon-bleu (Cobl). Cobl is a brain-enriched protein using three Wiskott-Aldrich syndrome protein homology 2 (WH2) domains for actin binding. Cobl promotes nonbundled, unbranched filaments. Filament...
متن کاملCordon-Bleu uses WH2 domains as multifunctional dynamizers of actin filament assembly.
Cordon-Bleu is, like Spire, a member of the growing family of WH2 repeat proteins, which emerge as versatile regulators of actin dynamics. They are expressed in morphogenetic and patterning processes and nucleate actin assembly in vitro. Here, we show that Cordon-Bleu works as a dynamizer of actin assembly by combining many properties of profilin with weak filament nucleating and powerful filam...
متن کاملMolecular Analysis of Alternative Transcripts of the Equine Cordon-Bleu WH2 Repeat Protein-Like 1 (COBLL1) Gene
The purpose of this study was to investigate the alternative splicing in equine cordon-bleu WH2 repeat protein-like 1 (COBLL1) gene that was identified in horse muscle and blood leukocytes, and to predict functional consequences of alternative splicing by bioinformatics analysis. In a previous study, RNA-seq analysis predicted the presence of alternative spliced isoforms of equine COBLL1, namel...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2003
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn1261